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Free, publicly-accessible full text available July 18, 2026
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Carson, James P; Fonner, John; Vaughn, Matthew; Niall, Gaffney; Brown, Tracy; Stubbs, Joe; Rosenburg, Jake; Tijerina, Sal; Allen, William J; Ferlanti, Erik; et al (, Zenodo)Large scale collaborative science requires tools to facilitate sharing of data, protocols, analysis tools, as well as data products and their provenance. We describe here two recent science gateways successfully deployed to accomplish collaborative research. The first is the Synergistic Discovery and Design Environment (SD2E), which was a web-based analysis platform for collaborative analysis, data sharing, and application development. The second is the 3D Electron Microscopy (3DEM) portal, which is a web-based research platform focused on developing and disseminating new technologies for enhanced resolution 3DEM. Both gateways were hosted and connected to high-performance computing resources at the Texas Advanced Computing Center.more » « less
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Hayashi, Soichi; Caron, Bradley A.; Heinsfeld, Anibal Sólon; Vinci-Booher, Sophia; McPherson, Brent; Bullock, Daniel N.; Bertò, Giulia; Niso, Guiomar; Hanekamp, Sandra; Levitas, Daniel; et al (, Nature Methods)Abstract Neuroscience is advancing standardization and tool development to support rigor and transparency. Consequently, data pipeline complexity has increased, hindering FAIR (findable, accessible, interoperable and reusable) access. brainlife.io was developed to democratize neuroimaging research. The platform provides data standardization, management, visualization and processing and automatically tracks the provenance history of thousands of data objects. Here, brainlife.io is described and evaluated for validity, reliability, reproducibility, replicability and scientific utility using four data modalities and 3,200 participants.more » « less
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